Essay heading: - Investigation of the role of MicroRNA- 223, MicroRNA -381 and MicroRNA- 505 in the regulation of transcription factor NFI-A.
Essay specific features
August 21, 2008
No of pages / words:
8 / 1981
Rating of current essay:
Genomic analyses have shown that one third of human genes could be miRNA targets. (Lewis et al. 2005).
This offers a potential method to control the expression of NFIA and thus indirectly, cell survival.
The translational inhibition of mRNAs is dependent on the binding of micro RNAs to target sequences in the 3’UTR of these mRNAs...
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Prominent binding sites for miR-505 and miR-381 and miR-223 have been identified on the far end of the human NFIA 3’ UTR. This in turn indicates likely neuroprotective functions arising from the regulation of miR-223, miR-381 and miR-505, and the mRNA of the transcription factors they bind to.
The luciferase gene encodes a protein that oxidises the substrate luciferin, generating visible light...
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General issues of this essay:
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