Essay heading: - Investigation of the role of MicroRNA- 223, MicroRNA -381 and MicroRNA- 505 in the regulation of transcription factor NFI-A.

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August 21, 2008






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8 / 1981


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Genomic analyses have shown that one third of human genes could be miRNA targets. (Lewis et al. 2005). This offers a potential method to control the expression of NFIA and thus indirectly, cell survival. Hypothesis The translational inhibition of mRNAs is dependent on the binding of micro RNAs to target sequences in the 3’UTR of these mRNAs...
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Prominent binding sites for miR-505 and miR-381 and miR-223 have been identified on the far end of the human NFIA 3’ UTR. This in turn indicates likely neuroprotective functions arising from the regulation of miR-223, miR-381 and miR-505, and the mRNA of the transcription factors they bind to. The luciferase gene encodes a protein that oxidises the substrate luciferin, generating visible light...
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