Biology

Essay specific features

 

Issue:

Technology

 

Written by:

Amy S

 

Date added:

June 23, 2010

 

Level:

University

 

Grade:

A

 

No of pages / words:

3 / 703

 

Was viewed:

9133 times

 

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Essay content:

But because of issues with stereochemistry, chemists are currently limited to extending peptides from the nitrogen end. "This is such a profound problem that the impossibility of synthesising peptides from the acid terminus has become dogma in the field" - Lawrence Harwood 'Conventional peptide synthesis is always carried out in a very linear manner, building the peptide chain from the nitrogen terminus, as attempts to grow peptide chains from the acid terminus result in scrambling of the stereochemistry,' explains Harwood...
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'This is such a profound problem that the impossibility of synthesising peptides from the acid terminus has become dogma in the field of peptide synthesis.' However, Harwood is new to the peptide field. 'We weren't steeped in this dogma, and didn't realise this reaction shouldn't be able to happen, so we just went away and did it,' he adds...
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