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Function of Actin

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Issue:

Science

 

Written by:

Walter B

 

Date added:

June 9, 2015

 

Level:

University

 

Grade:

A

 

No of pages / words:

1 / 243

 

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8136 times

 

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Although the actin isoforms exhibit minor sequence differences, they have different functions that can not be substituted by one another in vivo (3). In general, alpha-actin isoforms (?-skeletal, ?-aortic smooth, ?-cardiac, and ?2-enteric smooth) are found in muscle cells and they are associated with muscle contraction (3)...
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Beta-actin and gamma-actin isoforms present in nonmusle cells (2). Beta-actin is at the front of a moving cell where actin filaments polymerize to drive the membrane forward (2). Gamma-actin is found in stress fibers, which are important for cell growth and cell movement (1). Actin is used in laboratory for teaching purpose because 1) it is a well-studied protein at both gene level and amino acid level; 2) it is structurally simple (monomer); 3) it is abundant; and 4) it is biologically significant...
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