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Issue:

Science

 

Written by:

Julia A

 

Date added:

May 11, 2016

 

Level:

University

 

Grade:

A

 

No of pages / words:

12 / 3330

 

Was viewed:

4543 times

 

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Essay content:

Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein in?uenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection. An outbreak of H5N1 influenza A virus in Hong Kong in 1997 resulted in 6 deaths among 18 people infected (1–3)...
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The virulence seen in mice when infected with these human isolates showed some correspondence with the severity of disease in adult patients, although there are exceptions (3–7). To determine the molecular basis for the difference in virulence among Hong Kong H5N1 viruses, we generated reassortants between virulent and avirulent viruses (Fig...
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