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Essay

Rheumatoid Arthritis

Essay specific features

 

Issue:

Science

 

Written by:

Jessie H

 

Date added:

June 3, 2015

 

Level:

University

 

Grade:

A

 

No of pages / words:

16 / 4202

 

Was viewed:

9567 times

 

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Essay content:

Elevated expression of MIF in the circulation and in the synovial joint has been documented in rheumatoid arthritis. MIF also has been linked to the development of joint damage and disease pathology in experimental animal models. We describe herein a novel CATT-tetranucleotide repeat polymorphism at position -794 of the human Mif gene and show that it functionally affects the activity of the MIF promoter in gene reporter assays...
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We describe four genotypes which comprise 5, 6, 7, or 8-CATT repeat units and show that the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro. The presence of the low expressing, 5-CATT repeat allele correlated with low disease severity in a cohort of rheumatoid arthritis patients...
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