have heart failure. Patients with severe form of the disease have trouble breathing because the heart cannot pump fluid out of their lungs. Seventy percent die of the disease within 10 years, and the five-year survival rate is less than 50 percent. Heart failure is the only cardiovascular disease whose incidence has been increasing rather than decreasing...
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Heart failure is the only cardiovascular disease whose incidence has been increasing rather than decreasing. The multicenter national trial is funded and administered by the Celladon Corporation of La Jolla, Calif. The company has reported that the therapy, called MYDICAR®, has been shown to lead to significant improvements in heart function without significant safety concerns in large-animal models of heart failure...
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gene therapy The inserted ADA gene then programmed the cells to produce the missing ADA enzyme, which led to normal immune function in those cells. This treatment temporarily helped her to develop resistance to infection...	2 / 409
Safety of gene therapy Jesse Gelsinger was the first person publicly identified as having died in a clinical trial for gene therapy (Lamb et al. 2008), also two of the ten children treated at the trial's Paris center for treating children with SCID (severe combined immune deficiency), developed a leukemia-like condition (Thomas et al...	2 / 374
Gene Therapy Key ethical issues: ? What is normal and what is a disability or disorder, and who decides? ? Are disabilities diseases? Do they need to be cured or prevented? ? Does searching for a cure demean the lives of individuals presently affected by disabilities? ? Is somatic gene therapy (which is done in the adult cells of persons known to have the disease) more or less ethical than germline gene therapy (which is done in egg and sperm cells and prevents the trait from being passed on to further generations)? In cases of somatic gene therapy, the procedure may have to be repeated in future generations...	1 / 233
GENE THERAPY If it does, the parents can choose embryo therapy to cure it rather then abortion. While the basic process is similar with the one of patient therapy, to do an embryo therapy is a little bit easier than a patient therapy, because the immune rejection system of the embryo is not fully developed...	3 / 573