It has various causes mitral valve prolapse, rheumatic heart disease, infective endocarditis, CAD, connective tissue disease (Marfan Syndrome) and congestive cardiomyopathty. In mitral regurgitation the left ventricle becomes dilated and hypertrophied to maintain adequate cardiac output, despite increase volume from the left atrium...
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In mitral regurgitation the left ventricle becomes dilated and hypertrophied to maintain adequate cardiac output, despite increase volume from the left atrium. The volume of backflow reentering the left atrium gradually increases, causing atrial dilation. As the left atrium enlarges, the valve structures stretch and become deformed, left ventricular function may become impaired to the point of failure...
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