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Essay

Alexander Disease

Essay specific features

 

Issue:

Science

 

Written by:

Theodore L

 

Date added:

October 10, 2011

 

Level:

University

 

Grade:

A

 

No of pages / words:

3 / 836

 

Was viewed:

1945 times

 

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Essay content:

GFAP is glial fibrallary acidic protein (5). The mutation of the gene that codes for GFAP is thought to disturb the normal formation of regular intermediate filaments; this disturbance may cause a buildup of what is known as Rosenthal fibers which impede the duties of astrocytes, or astroglial cells (3, 4)...
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It is not sure among the medical community, the purpose of these astroglial cells in conjunction with the myelin sheathes, but it is thought that they assist in the creation and maintenance of it and the presence of the Rosenthal fibers simply blocks or interrupts their maintenance (4, 8). Common symptoms associated with myelin degeneration in Alexander’s Disease and other leukodystophies are: an enlarged head size, failure to gain weight, delays in the development of mental, physical and behavioral skills, muscle stiffness as the disease progresses, and general neurological deterioration (1, 2, 3, 4, 6)...
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