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Asthma
Essay specific features
Written by:
Randy S
Date added:
May 26, 2011
Level:
University
Grade:
A
No of pages / words:
2 / 373
Was viewed:
7792 times
Rating of current essay:
Essay content:
Bronchiodilators are a class of drug that relaxes airway smooth muscle by increasing cAMP and opening potassium channels. Corticosteriods on the other hand are now considered the first line of treatment for patients with severe and chronic asthma. Corticosteriods bind to a receptor in the cytosol, which translocates to the nucleus and binds DNA to activate genes...
displayed 300 characters
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Corticosteriods bind to a receptor in the cytosol, which translocates to the nucleus and binds DNA to activate genes. The main action of corticosteriods is to suppress multiple inflammatory genes, such as cytokines, inflammatory enzymes and adhesion molecules. The effectiveness of the corticosteriod is in most part due to the inhibition of transcription factors, such as AP-1 (activation protein 1), Nuclear factor-?b (NF-?b), and nuclear factor of activated T-cells (NF-AT), which are required for inflammatory response...
displayed 300 characters
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