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Cell-Penetrating Peptide Conjugates Of Peptide Nucleic Acids (Pna) As Inhibitors Of Hiv-1 Tat-Dependent Trans-Activation In Cells

Essay specific features

 

Issue:

Science

 

Written by:

Sandra J

 

Date added:

October 18, 2010

 

Level:

University

 

Grade:

B

 

No of pages / words:

2 / 310

 

Was viewed:

3193 times

 

Rating of current essay:

 
Essay content:

Revised November 14, 2005. Accepted November 14, 2005. The trans-activation response (TAR) RNA stem–loop that occurs at the 5' end of HIV RNA transcripts is an important antiviral target and is the site of interaction of the HIV-1 Tat protein together with host cellular factors. Oligonucleotides and their analogues targeted to TAR are potential antiviral candidates...
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Oligonucleotides and their analogues targeted to TAR are potential antiviral candidates. We have investigated a range of cell penetrating peptide (CPP) conjugates of a 16mer peptide nucleic acid (PNA) analogue targeted to the apical stem–loop of TAR and show that disulfide-linked PNA conjugates of two types of CPP (Transportan or a novel chimeric peptide R6-Penetratin) exhibit dose-dependent inhibition of Tat-dependent trans-activation in a HeLa cell assay when incubated for 24 h...
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General issues of this essay:
Cell Membrane/ Electron Transport Chain / Biochemical Pathway Cells History Of Cell Membrane Nucleic Acids Cells Cell-Penetrating Peptide Conjugates Of Peptide Nucleic Acids (Pna) As Inhibitors Of Hiv-1 Tat-Dependent Trans-Activation In Cells Cells And Cell Theory Cells Cells cells cells Investigating The Effect Of Temperature On The Permeability Of The Cell Membrane Of Beetroot Solid Phase Peptide Synthesis (SPPS) Stem Cells: What You Should Know About Stem Cells Before You Decide Wh The Cell Membrane
 

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