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Essay

Chronic Myeloid Leukemia

Essay specific features

 

Issue:

Science

 

Written by:

Martin F

 

Date added:

April 1, 2012

 

Level:

University

 

Grade:

A

 

No of pages / words:

4 / 1025

 

Was viewed:

813 times

 

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Essay content:

This translocation results in the transfer of the Abelson (ABL) on chromosome 9 oncogene to an area of chromosome 22 termed the breakpoint cluster region (BCR). The resulting hybrid gene ABL-BCR encodes for a protein of p210 or p185 weight from the tyrosine-kinase group. A tyrosine-kinase activates signal pathways, leading to the uncontrolled cell growth associated with this type of cancer...
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A tyrosine-kinase activates signal pathways, leading to the uncontrolled cell growth associated with this type of cancer. Specifically, the protein interacts with a 3beta(c) receptor subunit, activating the cell cycle and speeding up cell division. CML then proceeds through 3 phases: Chronic, accelerated, and blast crisis...
displayed 300 characters

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