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Concomitant radio-chemotherapy based on platin

Essay specific features

 

Issue:

Science

 

Written by:

Saul L

 

Date added:

July 12, 2013

 

Level:

University

 

Grade:

A

 

No of pages / words:

26 / 7113

 

Was viewed:

879 times

 

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Essay content:

The NSCLC Collaborative Group meta-analysis [3] showed that sequential cisplatin-based chemotherapy given in addition to radical radiotherapy prolonged survival in patients with locally advanced NSCLC. However, the prognosis for these patients remained poor with a 3-year survival rate of approximately 14%...
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Cytotoxic agents used as radiosensitisers given at the same time as radiotherapy have been evaluated against radiotherapy alone in several randomised trials [4–14]. A primary aim of this combined approach was to improve survival by increasing loco-regional control, while the sequential use of chemotherapy has been directed at reducing the rate of distant metastasis...
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