Current Theories Of The Etiology Of Nsaid Induced Renal Papillary Necrosis

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Issue:

Science

 

Written by:

Emma F

 

Date added:

December 10, 2014

 

Level:

University

 

Grade:

A

 

No of pages / words:

2 / 373

 

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2939 times

 

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Essay content:

Since prostaglandin H synthase is inhibited by NSAIDs production of prostaglandins cannot occur, which results in vasoconstriction and causes decreased blood flow resulting in ischemic necrosis. Due to the presence of high concentrations of toxins in the papillae and the ability of the papillary cells to produce reactive metabolites, the reactive metabolites produced cause oxidative stress...
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Since prostaglandin H synthase is inhibited by NSAIDs production of prostaglandins cannot occur, which results in vasoconstriction and causes decreased blood flow resulting in ischemic necrosis. Due to the presence of high concentrations of toxins in the papillae and the ability of the papillary cells to produce reactive metabolites, the reactive metabolites produced cause oxidative stress...
displayed 300 characters

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