This also means that pannus tissue will start to form where mass of synovium with synovial stroma containing the granulation tissue, inflammatory cells and fibroblasts starts to grow over the articular cartilage.
Activated T cells and the synovial fibroblast will produce RANKL that activates osteoclast and promotes bone destruction which allows synovium to penetrate into the bone and form juxta-articular erosions, subchondral cysts and osteoporosis in later stage of RA
So the stages of joint inflammation:
1st stage: synovitis (inflammation of synovial membrane) developing from the congestion and oedema of the membrane lining and joint capsule
2nd stage: formation of the pannus (thickened layer if synovium and synovial stroma consisting of the inflammatory cells(macrophages,neutrophils,etc),granulation tissue& fibroblasts) which grows over the cartilage depriving it from its nutrients which I would think lead to the cell death(necrosis) and as it is avascular it cannot repair itself &eventually destroy the joint capsule and bone performed by the enzymes produced by the synovial cells... displayed 300 characters
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This also means that pannus tissue will start to form where mass of synovium with synovial stroma containing the granulation tissue, inflammatory cells and fibroblasts starts to grow over the articular cartilage.
Activated T cells and the synovial fibroblast will produce RANKL that activates osteoclast and promotes bone destruction which allows synovium to penetrate into the bone and form juxta-articular erosions, subchondral cysts and osteoporosis in later stage of RA
So the stages of joint inflammation:
1st stage: synovitis (inflammation of synovial membrane) developing from the congestion and oedema of the membrane lining and joint capsule
2nd stage: formation of the pannus (thickened layer if synovium and synovial stroma consisting of the inflammatory cells(macrophages,neutrophils,etc),granulation tissue& fibroblasts) which grows over the cartilage depriving it from its nutrients which I would think lead to the cell death(necrosis) and as it is avascular it cannot repair itself &eventually destroy the joint capsule and bone performed by the enzymes produced by the synovial cells... displayed 300 characters
