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Investigation On The Effect Of Extracellular Calcium Concentration On Cardiac Function In The Langendorff Perfused Rat Heart
Essay specific features
Written by:
Warren D
Date added:
October 29, 2015
Level:
University
Grade:
C
No of pages / words:
9 / 2357
Was viewed:
8223 times
Rating of current essay:
Essay content:
Calcium binds to the ryanodine receptor on the sarcoplasmic reticulum which then causes vast release of more calcium. This calcium then forms cross-bridges by binding to the troponin.
Calcium binds to tropinin-C to induce a conformational change which moves tropinin-I away from actin/tropomyosin. Tropomyosin then moves to clear the myosin binding site on the actin thus allowing cross bridge attachment...
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Tropomyosin then moves to clear the myosin binding site on the actin thus allowing cross bridge attachment. Hence, contraction is critically dependent on intracellular calcium concentrations.
The process of cross-bridges formation and the shortening of the individual cardiomyocyte require ATP (phosphate group)...
displayed 300 characters
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