Investigation On The Effect Of Extracellular Calcium Concentration On Cardiac Function In The Langendorff Perfused Rat Heart

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Issue:

Science

 

Written by:

Warren D

 

Date added:

October 29, 2015

 

Level:

University

 

Grade:

C

 

No of pages / words:

9 / 2357

 

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8230 times

 

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Essay content:

Calcium binds to the ryanodine receptor on the sarcoplasmic reticulum which then causes vast release of more calcium. This calcium then forms cross-bridges by binding to the troponin. Calcium binds to tropinin-C to induce a conformational change which moves tropinin-I away from actin/tropomyosin. Tropomyosin then moves to clear the myosin binding site on the actin thus allowing cross bridge attachment...
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Tropomyosin then moves to clear the myosin binding site on the actin thus allowing cross bridge attachment. Hence, contraction is critically dependent on intracellular calcium concentrations. The process of cross-bridges formation and the shortening of the individual cardiomyocyte require ATP (phosphate group)...
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