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Leading and Lagging strand synthesis in DNA
Essay specific features
Written by:
Earnest M
Date added:
September 5, 2014
Level:
University
Grade:
A
No of pages / words:
1 / 259
Was viewed:
9301 times
Rating of current essay:
Essay content:
continuous replication. The difference arises because of the different orientations of the parent template strands. The template of the leading strand is oriented in the 3'>>5' direction (according to the numbering of atoms in the sugar residues), which means that the leading strand itself is oriented in the opposite 5'>>3' direction, providing an -OH group at the 3' end for the continual addition of nucleotides by DNA polymerase, which moves forwards as the template strands unwind at the replication fork...
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However, the template of the lagging strand is oriented in a 5'>>3' direction, so the lagging strand itself is oriented in the 3'>>5' direction, and hence the DNA polymerase complex must move backwards away from the replication fork. Synthesis of the lagging strand proceeds not continuously, as on the leading strand, but discontinuously in a series of repeated steps...
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