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protein domains

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Issue:

Science

 

Written by:

Kyle J

 

Date added:

September 19, 2014

 

Level:

 

Grade:

A

 

No of pages / words:

5 / 1375

 

Was viewed:

1664 times

 

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Essay content:

Since the term was first used by Wetlaufer (1973) a number of definitions exist reflecting author bias, however all of the definitions agree that domains are independently folding compact units. Domains are frequently coded by exons and therefore have specific functionality. Among the many descriptions of protein domains the two most striking and simple are " Protein evolutionary units" and "Basic currency of Proteins"...
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Each domain can be described by its fold. While some proteins consist of a single domain, others consist of several or many. A number of globular protein chains consist of two or three domains appearing as 'lobes'. In other cases the domains may be of very different nature- for example some proteins located in cell membranes have a globular intracellular or extracellular domain distinct from that which spans the membrane...
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