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Review of Arginine-482 is not essential for the transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2)

Essay specific features

 

Issue:

Science

 

Written by:

Dana S

 

Date added:

October 16, 2013

 

Level:

University

 

Grade:

B

 

No of pages / words:

4 / 1071

 

Was viewed:

8039 times

 

Rating of current essay:

 
Essay content:

High relative resistance factors of 82 and 78 were determined for BCRP-G- and -R-expressing cells in growth experiments. BCRP-G-associated ATPase activity was stimulated by the interaction of erythromycin with BCRP-G. However, erythromycin did not stimulate ATPase activity in the non-expressing control...
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However, erythromycin did not stimulate ATPase activity in the non-expressing control. This data suggests that endogenous ABC multidrug transporters, which may be expressed at low levels in L. lactis, do not contribute to the observed erythromycin resistance and transport in BCRP-R- or BCRP-G-expressing cells...
displayed 300 characters

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