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Risk of Cardiovascular Events with Rofecoxib
Essay specific features
Written by:
Jean M
Date added:
March 11, 2014
Level:
University
Grade:
A
No of pages / words:
5 / 1301
Was viewed:
5444 times
Rating of current essay:
Essay content:
This justifies the withdrawal of rofecoxib from the market.
Introduction
Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) which selectively inhibits the cyclooxygenase-2 (COX-2) enzyme.1 It was developed by Merck & Co. for the treatment of acute inflammation in joints, without causing the gastrointestinal side effects associated with traditional NSAIDs...
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2).4 Studies in mice and humans showed that COX-2 is the dominant source of prostaglandin I2, causing vasodilation as well as inhibiting platelet aggregation and vascular proliferation.4 The individual cardiovascular effects of prostaglandin I2 contrast with those of thromboxane A2 ? the major COX-1 product of platelets which cause platelet aggregation, vasoconstriction and vascular proliferation...
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