"Although there are clearly many obstacles to overcome, it is significant that a roadmap of the derivation and use of stem cells for human heart disease is now conceivable."
In the Nature article, Srivastava and Ivey point to several challenges ahead:
? Developing the ability not only to guide and expand stem cells into the cardiac lineage but also to repress alternative cell fates
? Developing methods for safe delivery and proper integration of stem cells within patients' heart tissue to avoid such complications as arrhythmias (irregular heart beat)
? Solving immunological issues surrounding rejection
"Exciting new findings over the past five years indicate that stem cells could prove effective as protective or regenerative cardiac therapies," said Ivey, who was named in April one of seven current postdoctoral fellows participating in the Gladstone's new stem cell training program, funded by the California Institute for Regenerative Medicine... displayed 300 characters
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"Although there are clearly many obstacles to overcome, it is significant that a roadmap of the derivation and use of stem cells for human heart disease is now conceivable."
In the Nature article, Srivastava and Ivey point to several challenges ahead:
? Developing the ability not only to guide and expand stem cells into the cardiac lineage but also to repress alternative cell fates
? Developing methods for safe delivery and proper integration of stem cells within patients' heart tissue to avoid such complications as arrhythmias (irregular heart beat)
? Solving immunological issues surrounding rejection
"Exciting new findings over the past five years indicate that stem cells could prove effective as protective or regenerative cardiac therapies," said Ivey, who was named in April one of seven current postdoctoral fellows participating in the Gladstone's new stem cell training program, funded by the California Institute for Regenerative Medicine... displayed 300 characters
