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Essay

Stress response in TB

Essay specific features

 

Issue:

Science

 

Written by:

Randy S

 

Date added:

December 17, 2013

 

Level:

University

 

Grade:

A

 

No of pages / words:

28 / 7727

 

Was viewed:

9584 times

 

Rating of current essay:

 
Essay content:

None of the conventional anti-tuberculosis drugs are able to target these persisting bacilli. Development of drugs against such persisting bacilli is a constant challenge since the physiology of these dormant bacteria is still not understood at the molecular level. Some evidence suggests that the in vivo environment encountered by the persisting bacteria is anoxic and nutritionally starved...
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Based on these assumptions, anaerobic and starved cultures are used as models to study the molecular basis of dormancy. This review outlines the problem of persistence of M. tuberculosis and the various in vitro models used to study mycobacterial latency. The basis of selecting the nutritional starvation model has been outlined here...
displayed 300 characters

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