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Telomere Dysfunction and Evolution of Instestinal Carcinoma in Mice and Humans

Essay specific features

 

Issue:

Science

 

Written by:

Agnes R

 

Date added:

June 25, 2013

 

Level:

University

 

Grade:

C

 

No of pages / words:

3 / 731

 

Was viewed:

4629 times

 

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Essay content:

These mice had no telomerase activity that is needed to lengthen the telomeres of the parental chromosomes in the germ line so that the offspring of each consecutive generation would inherit the shorter version of chromosomes than the prior generation. This kind of manipulation provides a situation where each generation has shorter telomeres, which means greater telomere dysfunction, and thus greater chromosomal instability...
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This kind of manipulation provides a situation where each generation has shorter telomeres, which means greater telomere dysfunction, and thus greater chromosomal instability. If chromosomes are unstable, that means that they are more prone to chromosomal aberrations and promotion of the Apc-min allele deletion...
displayed 300 characters

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